Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke

In addition to its role in DNA repair, nuclear poly(ADP-ribose) polymerase-1 (PARP-1) mediates brain damage when it is over-activated by oxidative/nitrosative stress. Nonetheless, it remains unclear how PARP-1 is activated in neuropathological contexts. Here we report that PARP-1 interacts with a po...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Nakajima, Hidemitsu, Kubo, Takeya, Ihara, Hideshi, Hikida, Takatoshi, Danjo, Teruko, Nakatsuji, Masatoshi, Shahani, Neelam, Itakura, Masanori, Ono, Yoko, Azuma, Yasu-Taka, Inui, Takashi, Kamiya, Atsushi, Sawa, Akira, Takeuchi, Tadayoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505517/
https://ncbi.nlm.nih.gov/pubmed/25882840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.635607
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