Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death

Glycolytic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein that also mediates cell death under oxidative stress. We reported previously that the active-site cysteine (Cys-152) of GAPDH plays an essential role in oxidative stress-induced aggregation of GAPDH associated w...

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Vydáno v:J Biol Chem
Hlavní autoři: Nakajima, Hidemitsu, Itakura, Masanori, Kubo, Takeya, Kaneshige, Akihiro, Harada, Naoki, Izawa, Takeshi, Azuma, Yasu-Taka, Kuwamura, Mitsuru, Yamaji, Ryouichi, Takeuchi, Tadayoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377786/
https://ncbi.nlm.nih.gov/pubmed/28167533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.759084
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