Botulinum Neurotoxin Type A Subtype 2 Confers Greater Safety than Subtype 1 in a Rat Parkinson’s Disease Model

Botulinum neurotoxin type A (BoNT/A) cleaves SNAP-25 and interrupts the release of acetylcholine. We previously reported that BoNT/A subtype 2 (BoNT/A2) ameliorates pathologic behavior more effectively than subtype 1 (BoNT/A1) in a rat Parkinson’s disease model. Here, we further show BoNT/A2 has few...

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Autores principales: ITAKURA, Masanori, KOHDA, Tomoko, KUBO, Takeya, SEMI, Yuko, NISHIYAMA, Kazuhiro, AZUMA, Yasu-Taka, NAKAJIMA, Hidemitsu, KOZAKI, Shunji, TAKEUCHI, Tadayoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: The Japanese Society of Veterinary Science 2014
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155206/
https://ncbi.nlm.nih.gov/pubmed/24849052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.14-0184
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