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Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b)

Pancreatic islet β-cells that lack the MEN1-encoded protein menin develop into tumors. Such tumors express the phosphorylated isoform of the β-cell differentiation transcription factor HLXB9. It is not known how phospho-HLXB9 acts as an oncogenic factor in insulin-secreting β-cell tumors (insulinoma...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Desai, Shruti S., Kharade, Sampada S., Parekh, Vaishali I., Iyer, Sucharitha, Agarwal, Sunita K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646204/
https://ncbi.nlm.nih.gov/pubmed/26342078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661413
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