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T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency

Autoimmune polyendocrinopathy syndrome type 1 (APS1) results from homozygous Aire mutations that cripple thymic deletion of organ-specific T cells. The clinical course in man and mouse is characterized by high variability both in the latent period before onset of autoimmune disease and in the specif...

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Hlavní autoři: Teh, Charis E., Daley, Stephen R., Enders, Anselm, Goodnow, Christopher C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930471/
https://ncbi.nlm.nih.gov/pubmed/20668237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009209107
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