Myostatin Induces Insulin Resistance via Casitas B-Lineage Lymphoma b (Cblb)-mediated Degradation of Insulin Receptor Substrate 1 (IRS1) Protein in Response to High Calorie Diet Intake

To date a plethora of evidence has clearly demonstrated that continued high calorie intake leads to insulin resistance and type-2 diabetes with or without obesity. However, the necessary signals that initiate insulin resistance during high calorie intake remain largely unknown. Our results here show...

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Bibliographic Details
Main Authors: Bonala, Sabeera, Lokireddy, Sudarsanareddy, McFarlane, Craig, Patnam, Sreekanth, Sharma, Mridula, Kambadur, Ravi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953277/
https://ncbi.nlm.nih.gov/pubmed/24451368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529925
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