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μ-Opioid receptor 6-transmembrane isoform: a potential therapeutic target for new effective opioids

The μ-opioid receptor (MOR) is the primary target for opioid analgesics. MOR induces analgesia through the inhibition of second messenger pathways and the modulation of ion channels activity. Nevertheless, cellular excitation has also been demonstrated, and proposed to mediate reduction of therapeut...

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Dades bibliogràfiques
Publicat a:Prog Neuropsychopharmacol Biol Psychiatry
Autors principals: Convertino, Marino, Samoshkin, Alexander, Gauthier, Josee, Gold, Michael S., Maixner, William, Dokholyan, Nikolay V., Diatchenko, Luda
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646084/
https://ncbi.nlm.nih.gov/pubmed/25485963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pnpbp.2014.11.009
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