Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine Stimulation

The pharmacological effect of opioids originates, at the cellular level, by their interaction with the μ-opioid receptor (mOR) resulting in the regulation of voltage-gated Ca(2+) channels and inwardly rectifying K(+) channels that ultimately modulate the synaptic transmission. Recently, an alternati...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Convertino, Marino, Samoshkin, Alexander, Viet, Chi T., Gauthier, Josee, Li Fraine, Steven P., Sharif-Naeini, Reza, Schmidt, Brian L., Maixner, William, Diatchenko, Luda, Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640872/
https://ncbi.nlm.nih.gov/pubmed/26554831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142826
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