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Structural basis for mu-opioid receptor binding and activation
Opioids that stimulate the μ-opioid receptor (MOR1) are the most frequently prescribed and effective analgesics. Here we present a structural model of MOR1. Molecular dynamics simulations show a ligand-dependent increase in the conformational flexibility of the third intracellular loop that couples...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217204/ https://ncbi.nlm.nih.gov/pubmed/22078567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.08.003 |
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