Structural and functional interactions between six-transmembrane μ-opioid receptors and β(2)-adrenoreceptors modulate opioid signaling

The primary molecular target for clinically used opioids is the μ-opioid receptor (MOR). Besides the major seven-transmembrane (7TM) receptors, the MOR gene codes for alternatively spliced six-transmembrane (6TM) isoforms, the biological and clinical significance of which remains unclear. Here, we s...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Samoshkin, Alexander, Convertino, Marino, Viet, Chi T., Wieskopf, Jeffrey S., Kambur, Oleg, Marcovitz, Jaclyn, Patel, Pinkal, Stone, Laura S., Kalso, Eija, Mogil, Jeffrey S., Schmidt, Brian L., Maixner, William, Dokholyan, Nikolay V., Diatchenko, Luda
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676002/
https://ncbi.nlm.nih.gov/pubmed/26657998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18198
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