Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

Two hypertrophic cardiomyopathy-associated cardiac troponin I (cTnI) mutations, R146G and R21C, are located in different regions of cTnI, the inhibitory peptide and the cardiac-specific N terminus. We recently reported that these regions may interact when Ser-23/Ser-24 are phosphorylated, weakening...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Cheng, Yuanhua, Rao, Vijay, Tu, An-yue, Lindert, Steffen, Wang, Dan, Oxenford, Lucas, McCulloch, Andrew D., McCammon, J. Andrew, Regnier, Michael
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646022/
https://ncbi.nlm.nih.gov/pubmed/26391394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.683045
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