PKA Phosphorylation of Cardiac Troponin I Modulates Activation and Relaxation Kinetics of Ventricular Myofibrils

Protein kinase A (PKA) phosphorylation of myofibril proteins constitutes an important pathway for β-adrenergic modulation of cardiac contractility and relaxation. PKA targets the N-terminus (Ser-23/24) of cardiac troponin I (cTnI), cardiac myosin-binding protein C (cMyBP-C) and titin. The effect of...

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Bibliographic Details
Main Authors: Rao, Vijay, Cheng, Yuanhua, Lindert, Steffen, Wang, Dan, Oxenford, Lucas, McCulloch, Andrew D., McCammon, J. Andrew, Regnier, Michael
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2014
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156663/
https://ncbi.nlm.nih.gov/pubmed/25185555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.027
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