Computational Studies of the Effect of the S23D/S24D Troponin I Mutation on Cardiac Troponin Structural Dynamics

During β-adrenergic stimulation, cardiac troponin I (cTnI) is phosphorylated by protein kinase A (PKA) at sites S23/S24, located at the N-terminus of cTnI. This phosphorylation has been shown to decrease K(Ca) and pCa(50), and weaken the cTnC-cTnI (C-I) interaction. We recently reported that phospho...

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Autori principali: Cheng, Yuanhua, Lindert, Steffen, Kekenes-Huskey, Peter, Rao, Vijay S., Solaro, R. John, Rosevear, Paul R., Amaro, Rommie, McCulloch, Andrew D., McCammon, J. Andrew, Regnier, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2014
Soggetti:
Proteins and Nucleic Acids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190606/
https://ncbi.nlm.nih.gov/pubmed/25296321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.08.008
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