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Computational Studies of the Effect of the S23D/S24D Troponin I Mutation on Cardiac Troponin Structural Dynamics
During β-adrenergic stimulation, cardiac troponin I (cTnI) is phosphorylated by protein kinase A (PKA) at sites S23/S24, located at the N-terminus of cTnI. This phosphorylation has been shown to decrease K(Ca) and pCa(50), and weaken the cTnC-cTnI (C-I) interaction. We recently reported that phospho...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4190606/ https://ncbi.nlm.nih.gov/pubmed/25296321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.08.008 |
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