The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes

The spliceosome is a dynamic complex of five structural RNAs and dozens of proteins, which assemble together to remove introns from nascent eukaryotic gene transcripts in a process called splicing. Small molecules that target different components of the spliceosome represent valuable research tools...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Effenberger, Kerstin A., James, Robert C., Urabe, Veronica K., Dickey, Bailey J., Linington, Roger G., Jurica, Melissa S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646004/
https://ncbi.nlm.nih.gov/pubmed/26408199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.673210
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