Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Core Nuclear Egress Complex Provides Insight into a Unique Assembly Scaffold for Virus-Host Protein Interactions

Nuclear replication of cytomegalovirus relies on elaborate mechanisms of nucleocytoplasmic egress of viral particles. Thus, the role of two essential and conserved viral nuclear egress proteins, pUL50 and pUL53, is pivotal. pUL50 and pUL53 heterodimerize and form a core nuclear egress complex (NEC),...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Walzer, Sascha A., Egerer-Sieber, Claudia, Sticht, Heinrich, Sevvana, Madhumati, Hohl, Katharina, Milbradt, Jens, Muller, Yves A., Marschall, Manfred
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645997/
https://ncbi.nlm.nih.gov/pubmed/26432641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C115.686527
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