Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Core Nuclear Egress Complex Provides Insight into a Unique Assembly Scaffold for Virus-Host Protein Interactions

Nuclear replication of cytomegalovirus relies on elaborate mechanisms of nucleocytoplasmic egress of viral particles. Thus, the role of two essential and conserved viral nuclear egress proteins, pUL50 and pUL53, is pivotal. pUL50 and pUL53 heterodimerize and form a core nuclear egress complex (NEC),...

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Publicado en:J Biol Chem
Autores principales: Walzer, Sascha A., Egerer-Sieber, Claudia, Sticht, Heinrich, Sevvana, Madhumati, Hohl, Katharina, Milbradt, Jens, Muller, Yves A., Marschall, Manfred
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645997/
https://ncbi.nlm.nih.gov/pubmed/26432641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C115.686527
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