Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus

Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five ot...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: Van Poucke, Sjouke, Doedt, Jennifer, Baumann, Jan, Qiu, Yu, Matrosovich, Tatyana, Klenk, Hans-Dieter, Van Reeth, Kristien, Matrosovich, Mikhail
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2015
Aiheet:
Virus-Cell Interactions
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645308/
https://ncbi.nlm.nih.gov/pubmed/26378170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01292-15
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