Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus

Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five ot...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Van Poucke, Sjouke, Doedt, Jennifer, Baumann, Jan, Qiu, Yu, Matrosovich, Tatyana, Klenk, Hans-Dieter, Van Reeth, Kristien, Matrosovich, Mikhail
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645308/
https://ncbi.nlm.nih.gov/pubmed/26378170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01292-15
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