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Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus
Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five ot...
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| Опубликовано в: : | J Virol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4645308/ https://ncbi.nlm.nih.gov/pubmed/26378170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01292-15 |
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