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Overexpression of the α-2,6-Sialyltransferase in MDCK Cells Increases Influenza Virus Sensitivity to Neuraminidase Inhibitors

No reliable cell culture assay is currently available for monitoring human influenza virus sensitivity to neuraminidase inhibitors (NAI). This can be explained by the observation that because of a low concentration of sialyl-α2,6-galactose (Sia[α2,6]Gal)-containing virus receptors in conventional ce...

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Detalhes bibliográficos
Main Authors: Matrosovich, Mikhail, Matrosovich, Tatyana, Carr, Jackie, Roberts, Noel A., Klenk, Hans-Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165236/
https://ncbi.nlm.nih.gov/pubmed/12857911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.15.8418-8425.2003
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