Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus

Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five ot...

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Bibliographic Details
Published in:J Virol
Main Authors: Van Poucke, Sjouke, Doedt, Jennifer, Baumann, Jan, Qiu, Yu, Matrosovich, Tatyana, Klenk, Hans-Dieter, Van Reeth, Kristien, Matrosovich, Mikhail
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645308/
https://ncbi.nlm.nih.gov/pubmed/26378170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01292-15
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