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Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium

Host cell proteases that cleave the hemagglutinin (HA) of influenza viruses in the human respiratory tract are still not identified. Here we cloned two human type II transmembrane serine proteases with known airway localization, TMPRSS2 and HAT, into mammalian expression vector. Cotransfection of ma...

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Sonraí Bibleagrafaíochta
Main Authors: Böttcher, Eva, Matrosovich, Tatyana, Beyerle, Michaela, Klenk, Hans-Dieter, Garten, Wolfgang, Matrosovich, Mikhail
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617224/
https://ncbi.nlm.nih.gov/pubmed/16973594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01118-06
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