Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium

Host cell proteases that cleave the hemagglutinin (HA) of influenza viruses in the human respiratory tract are still not identified. Here we cloned two human type II transmembrane serine proteases with known airway localization, TMPRSS2 and HAT, into mammalian expression vector. Cotransfection of ma...

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Autores principales: Böttcher, Eva, Matrosovich, Tatyana, Beyerle, Michaela, Klenk, Hans-Dieter, Garten, Wolfgang, Matrosovich, Mikhail
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617224/
https://ncbi.nlm.nih.gov/pubmed/16973594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01118-06
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