Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium

Host cell proteases that cleave the hemagglutinin (HA) of influenza viruses in the human respiratory tract are still not identified. Here we cloned two human type II transmembrane serine proteases with known airway localization, TMPRSS2 and HAT, into mammalian expression vector. Cotransfection of ma...

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Bibliografiska uppgifter
Huvudupphovsmän: Böttcher, Eva, Matrosovich, Tatyana, Beyerle, Michaela, Klenk, Hans-Dieter, Garten, Wolfgang, Matrosovich, Mikhail
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2006
Ämnen:
Virus-Cell Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617224/
https://ncbi.nlm.nih.gov/pubmed/16973594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01118-06
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