Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function

[Image: see text] Several new mercaptoacetamides were synthesized and studied as HDAC6 inhibitors. One compound, 2b, bearing an aminoquinoline cap group, was found to show 1.3 nM potency at HDAC6, with >3000-fold selectivity over HDAC1. 2b also showed excellent efficacy at increasing tubulin acet...

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Publicado en:ACS Med Chem Lett
Autores principales: Segretti, Mariana C. F., Vallerini, Gian Paolo, Brochier, Camille, Langley, Brett, Wang, Liqing, Hancock, Wayne W., Kozikowski, Alan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2015
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645251/
https://ncbi.nlm.nih.gov/pubmed/26617971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00303
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