Matrix remodeling promotes pulmonary hypertension through feedback mechanoactivation of the YAP/TAZ-miR-130/301 circuit

Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vascular cell types, such ECM stiffening induced the microRN...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Rep
मुख्य लेखकों: Bertero, Thomas, Cottrill, Katherine A., Lu, Yu, Haeger, Christina M., Dieffenbach, Paul, Annis, Sofia, Hale, Andrew, Bhat, Balkrishen, Kaimal, Vivek, Zhang, Ying-Yi, Graham, Brian B., Kumar, Rahul, Saggar, Rajan, Saggar, Rajeev, Wallace, W. Dean, Ross, David J., Black, Stephen M., Fratz, Sohrab, Fineman, Jeffrey R., Vargas, Sara O., Haley, Kathleen J., Waxman, Aaron B., Chau, B. Nelson, Fredenburgh, Laura E., Chan, Stephen Y.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644508/
https://ncbi.nlm.nih.gov/pubmed/26565914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.049
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