Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertension (PH). However, the mechanisms by which biophysical properties of the vascular extracellular matrix (ECM) relate to metabolic processes important in PH remain undefined. In this work, we examined cultur...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Bertero, Thomas, Oldham, William M., Cottrill, Katherine A., Pisano, Sabrina, Vanderpool, Rebecca R., Yu, Qiujun, Zhao, Jingsi, Tai, Yiyin, Tang, Ying, Zhang, Ying-Yi, Rehman, Sofiya, Sugahara, Masataka, Qi, Zhi, Gorcsan, John, Vargas, Sara O., Saggar, Rajan, Saggar, Rajeev, Wallace, W. Dean, Ross, David J., Haley, Kathleen J., Waxman, Aaron B., Parikh, Victoria N., De Marco, Teresa, Hsue, Priscilla Y., Morris, Alison, Simon, Marc A., Norris, Karen A., Gaggioli, Cedric, Loscalzo, Joseph, Fessel, Joshua, Chan, Stephen Y.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004943/
https://ncbi.nlm.nih.gov/pubmed/27548520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86387
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