Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertension (PH). However, the mechanisms by which biophysical properties of the vascular extracellular matrix (ECM) relate to metabolic processes important in PH remain undefined. In this work, we examined cultur...

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Publicado en:J Clin Invest
Main Authors: Bertero, Thomas, Oldham, William M., Cottrill, Katherine A., Pisano, Sabrina, Vanderpool, Rebecca R., Yu, Qiujun, Zhao, Jingsi, Tai, Yiyin, Tang, Ying, Zhang, Ying-Yi, Rehman, Sofiya, Sugahara, Masataka, Qi, Zhi, Gorcsan, John, Vargas, Sara O., Saggar, Rajan, Saggar, Rajeev, Wallace, W. Dean, Ross, David J., Haley, Kathleen J., Waxman, Aaron B., Parikh, Victoria N., De Marco, Teresa, Hsue, Priscilla Y., Morris, Alison, Simon, Marc A., Norris, Karen A., Gaggioli, Cedric, Loscalzo, Joseph, Fessel, Joshua, Chan, Stephen Y.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004943/
https://ncbi.nlm.nih.gov/pubmed/27548520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86387
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