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Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

The solubility of proteins is an essential requirement for their function. Yet these ubiquitous molecules can undergo aggregation when the protein homeostasis system becomes impaired. Here we ask which is the driving force for protein aggregation in the cellular environment. Emerging evidence sugges...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Trends Pharmacol Sci
Päätekijät: Ciryam, Prajwal, Kundra, Rishika, Morimoto, Richard I., Dobson, Christopher M., Vendruscolo, Michele
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643722/
https://ncbi.nlm.nih.gov/pubmed/25636813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2014.12.004
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