MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Maternal embryonic leucine zipper kinase (MELK), a serine/threonine protein kinase, has oncogenic properties and is overexpressed in many cancer cells. The oncogenic function of MELK is attributed to its capacity to disable critical cell-cycle checkpoints and reduce replication stress. Most function...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biosci Rep
Auteurs principaux: Beke, Lijs, Kig, Cenk, Linders, Joannes T. M., Boens, Shannah, Boeckx, An, van Heerde, Erika, Parade, Marc, De Bondt, An, Van den Wyngaert, Ilse, Bashir, Tarig, Ogata, Souichi, Meerpoel, Lieven, Van Eynde, Aleyde, Johnson, Christopher N., Beullens, Monique, Brehmer, Dirk, Bollen, Mathieu
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2015
Sujets:
Original Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643329/
https://ncbi.nlm.nih.gov/pubmed/26431963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150194
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