MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Maternal embryonic leucine zipper kinase (MELK), a serine/threonine protein kinase, has oncogenic properties and is overexpressed in many cancer cells. The oncogenic function of MELK is attributed to its capacity to disable critical cell-cycle checkpoints and reduce replication stress. Most function...

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Bibliografske podrobnosti
izdano v:Biosci Rep
Main Authors: Beke, Lijs, Kig, Cenk, Linders, Joannes T. M., Boens, Shannah, Boeckx, An, van Heerde, Erika, Parade, Marc, De Bondt, An, Van den Wyngaert, Ilse, Bashir, Tarig, Ogata, Souichi, Meerpoel, Lieven, Van Eynde, Aleyde, Johnson, Christopher N., Beullens, Monique, Brehmer, Dirk, Bollen, Mathieu
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2015
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643329/
https://ncbi.nlm.nih.gov/pubmed/26431963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150194
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