Načítá se...

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Maternal embryonic leucine zipper kinase (MELK), a serine/threonine protein kinase, has oncogenic properties and is overexpressed in many cancer cells. The oncogenic function of MELK is attributed to its capacity to disable critical cell-cycle checkpoints and reduce replication stress. Most function...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Biosci Rep
Hlavní autoři: Beke, Lijs, Kig, Cenk, Linders, Joannes T. M., Boens, Shannah, Boeckx, An, van Heerde, Erika, Parade, Marc, De Bondt, An, Van den Wyngaert, Ilse, Bashir, Tarig, Ogata, Souichi, Meerpoel, Lieven, Van Eynde, Aleyde, Johnson, Christopher N., Beullens, Monique, Brehmer, Dirk, Bollen, Mathieu
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643329/
https://ncbi.nlm.nih.gov/pubmed/26431963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150194
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!