Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells

Maternal embryonic leucine zipper kinase (MELK) belongs to the subfamily of AMP-activated Ser/Thr protein kinases. The expression of MELK is very high in glioblastoma-type brain tumors, but it is not clear how this contributes to tumor growth. Here we show that the siRNA-mediated loss of MELK in U87...

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Dettagli Bibliografici
Autori principali: Kig, Cenk, Beullens, Monique, Beke, Lijs, Van Eynde, Aleyde, Linders, Johannes T., Brehmer, Dirk, Bollen, Mathieu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745365/
https://ncbi.nlm.nih.gov/pubmed/23836907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.471433
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