Hydrogen peroxide-activatable antioxidant prodrug as a targeted therapeutic agent for ischemia-reperfusion injury

Overproduction of hydrogen peroxide (H(2)O(2)) causes oxidative stress and is the main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury. Suppression of oxidative stress is therefore critical in the treatment of I/R injury. Here, we report H(2)O(2)-activatable antioxidant prodrug (BRA...

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Publicado en:Sci Rep
Main Authors: Lee, Dongwon, Park, Seunggyu, Bae, Soochan, Jeong, Dahee, Park, Minhyung, Kang, Changsun, Yoo, Wooyoung, Samad, Mohammed A., Ke, Qingen, Khang, Gilson, Kang, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643254/
https://ncbi.nlm.nih.gov/pubmed/26563741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16592
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