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Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD

Abnormal expansions of an intronic hexanucleotide GGGGCC (G4C2) repeat of the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Previous studies suggested that the C9orf72 hexanucleotide repeat expansion (HRE), either as DNA or t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhou, Bo, Liu, Changdong, Geng, Yanyan, Zhu, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643247/
https://ncbi.nlm.nih.gov/pubmed/26564809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16673
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