Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence

The hexanucleotide repeat expansion, GGGGCC (G4C2), within the first intron of the C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The G4C2 repeat expansions, either DNA or RNA, are able to form G-quadruplexes w...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Geng, Yanyan, Liu, Changdong, Cai, Qixu, Luo, Zhipu, Miao, Haitao, Shi, Xiao, Xu, Naining, Fung, Chun Po, Choy, To To, Yan, Bing, Li, Ning, Qian, Peiyuan, Zhou, Bo, Zhu, Guang
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2021
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191786/
https://ncbi.nlm.nih.gov/pubmed/34048588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab302
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