Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence

The large expansion of GGGGCC (G4C2) repeats of the C9orf72 gene have been found to lead to the pathogenesis of devastating neurological diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The structural polymorphisms of C9orf72 HRE DNA and RNA may cause aberrant transcr...

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Udgivet i:Sci Rep
Main Authors: Zhou, Bo, Geng, Yanyan, Liu, Changdong, Miao, Haitao, Ren, Yaguang, Xu, Naining, Shi, Xiao, You, Yingying, Lee, Tunglun, Zhu, Guang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799222/
https://ncbi.nlm.nih.gov/pubmed/29402965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20852-w
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