Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

Several bifunctional peptides were synthesized and characterized based on the pentapeptide-derived ligand NP30 (1: Tyr-DAla-Gly-Phe-Gly-Trp-O-[3’,5’-Bzl(CF(3))(2)]). Modification and truncation of amino acid residues were performed, and the tripeptide-derived ligand NP66 (11: Dmt-DAla-Trp-NH-[3'...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Nair, Padma, Yamamoto, Takashi, Cowell, Scott, Kulkarni, Vinod, Moye, Sharif, Navratilova, Edita, Davis, Peg, Ma, Shou-Wu, Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Hruby, Victor J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642890/
https://ncbi.nlm.nih.gov/pubmed/26212775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.030
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