Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate mTOR complex 1 (mTORC1). Mutation or aberrant inhibition of the TSC complex...

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Detaylı Bibliyografya
Yayımlandı:Sci Signal
Asıl Yazarlar: Housden, Benjamin E., Valvezan, Alexander J., Kelley, Colleen, Sopko, Richelle, Hu, Yanhui, Roesel, Charles, Lin, Shuailiang, Buckner, Michael, Tao, Rong, Yilmazel, Bahar, Mohr, Stephanie E., Manning, Brendan D., Perrimon, Norbert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642709/
https://ncbi.nlm.nih.gov/pubmed/26350902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab3729
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