Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate mTOR complex 1 (mTORC1). Mutation or aberrant inhibition of the TSC complex...

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Bibliografske podrobnosti
izdano v:Sci Signal
Main Authors: Housden, Benjamin E., Valvezan, Alexander J., Kelley, Colleen, Sopko, Richelle, Hu, Yanhui, Roesel, Charles, Lin, Shuailiang, Buckner, Michael, Tao, Rong, Yilmazel, Bahar, Mohr, Stephanie E., Manning, Brendan D., Perrimon, Norbert
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642709/
https://ncbi.nlm.nih.gov/pubmed/26350902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab3729
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