Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate mTOR complex 1 (mTORC1). Mutation or aberrant inhibition of the TSC complex...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Signal
Autori principali: Housden, Benjamin E., Valvezan, Alexander J., Kelley, Colleen, Sopko, Richelle, Hu, Yanhui, Roesel, Charles, Lin, Shuailiang, Buckner, Michael, Tao, Rong, Yilmazel, Bahar, Mohr, Stephanie E., Manning, Brendan D., Perrimon, Norbert
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642709/
https://ncbi.nlm.nih.gov/pubmed/26350902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab3729
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi