AIF inhibits tumor metastasis by protecting PTEN from oxidation

Apoptosis-inducing factor (AIF) exerts dual roles on cell death and survival, but its substrates as a putative oxidoreductase and roles in tumorigenesis remain elusive. Here, we report that AIF physically interacts with and inhibits the oxidation of phosphatase and tensin homolog on chromosome ten (...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO Rep
Main Authors: Shen, Shao-Ming, Guo, Meng, Xiong, Zhong, Yu, Yun, Zhao, Xu-Yun, Zhang, Fei-Fei, Chen, Guo-Qiang
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641507/
https://ncbi.nlm.nih.gov/pubmed/26415504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540536
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