Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals

IMPORTANCE: Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymo...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:JAMA Neurol
Autori principali: Ghani, Mahdi, Reitz, Christiane, Cheng, Rong, Vardarajan, Badri Narayan, Jun, Gyungah, Sato, Christine, Naj, Adam, Rajbhandary, Ruchita, Wang, Li-San, Valladares, Otto, Lin, Chiao-Feng, Larson, Eric B., Graff-Radford, Neill R., Evans, Denis, De Jager, Philip L., Crane, Paul K., Buxbaum, Joseph D., Murrell, Jill R., Raj, Towfique, Ertekin-Taner, Nilufer, Logue, Mark, Baldwin, Clinton T., Green, Robert C., Barnes, Lisa L., Cantwell, Laura B., Fallin, M. Daniele, Go, Rodney C. P., Griffith, Patrick A., Obisesan, Thomas O., Manly, Jennifer J., Lunetta, Kathryn L., Kamboh, M. Ilyas, Lopez, Oscar L., Bennett, David A., Hendrie, Hugh, Hall, Kathleen S., Goate, Alison M., Byrd, Goldie S., Kukull, Walter A., Foroud, Tatiana M., Haines, Jonathan L., Farrer, Lindsay A., Pericak-Vance, Margaret A., Lee, Joseph H., Schellenberg, Gerard D., St. George-Hyslop, Peter, Mayeux, Richard, Rogaeva, Ekaterina
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641052/
https://ncbi.nlm.nih.gov/pubmed/26366463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1700
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi