Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)

Genetic variants in the sortilin-related receptor (SORL1) and the sortilin-related vacuolar protein sorting 10 (VPS10) domain-containing receptor 1 (SORCS1) are associated with increased risk of Alzheimer's disease (AD), declining cognitive function and altered amyloid precursor protein (APP) p...

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Autori principali: Reitz, C, Tosto, G, Vardarajan, B, Rogaeva, E, Ghani, M, Rogers, R S, Conrad, C, Haines, J L, Pericak-Vance, M A, Fallin, M D, Foroud, T, Farrer, L A, Schellenberg, G D, George-Hyslop, P S, Mayeux, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669917/
https://ncbi.nlm.nih.gov/pubmed/23673467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2013.13
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