SORCS1 Alters Amyloid Precursor Protein Processing and Variants May Increase Alzheimer’s Disease Risk

OBJECTIVE: Sorting mechanisms that cause the amyloid precursor protein (APP) and the β-secretases and γ-secretases to colocalize in the same compartment play an important role in the regulation of Aβ production in Alzheimer’s disease (AD). We and others have reported that genetic variants in the Sor...

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Main Authors: Reitz, Christiane, Tokuhiro, Shinya, Clark, Lorraine N., Conrad, Christopher, Vonsattel, Jean-Paul, Hazrati, Lili-Naz, Palotás, András, Lantigua, Raphael, Medrano, Martin, Jiménez-Velázquez, Ivonne Z., Vardarajan, Badri, Simkin, Irene, Haines, Jonathan L., Pericak-Vance, Margaret A., Farrer, Lindsay A., Lee, Joseph H., Rogaeva, Ekaterina, St. George-Hyslop, Peter, Mayeux, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086759/
https://ncbi.nlm.nih.gov/pubmed/21280075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22308
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