SORCS1 Alters Amyloid Precursor Protein Processing and Variants May Increase Alzheimer’s Disease Risk

OBJECTIVE: Sorting mechanisms that cause the amyloid precursor protein (APP) and the β-secretases and γ-secretases to colocalize in the same compartment play an important role in the regulation of Aβ production in Alzheimer’s disease (AD). We and others have reported that genetic variants in the Sor...

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Bibliografski detalji
Glavni autori: Reitz, Christiane, Tokuhiro, Shinya, Clark, Lorraine N., Conrad, Christopher, Vonsattel, Jean-Paul, Hazrati, Lili-Naz, Palotás, András, Lantigua, Raphael, Medrano, Martin, Jiménez-Velázquez, Ivonne Z., Vardarajan, Badri, Simkin, Irene, Haines, Jonathan L., Pericak-Vance, Margaret A., Farrer, Lindsay A., Lee, Joseph H., Rogaeva, Ekaterina, St. George-Hyslop, Peter, Mayeux, Richard
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086759/
https://ncbi.nlm.nih.gov/pubmed/21280075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22308
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