Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals

IMPORTANCE: Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymo...

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Published in:JAMA Neurol
Main Authors: Ghani, Mahdi, Reitz, Christiane, Cheng, Rong, Vardarajan, Badri Narayan, Jun, Gyungah, Sato, Christine, Naj, Adam, Rajbhandary, Ruchita, Wang, Li-San, Valladares, Otto, Lin, Chiao-Feng, Larson, Eric B., Graff-Radford, Neill R., Evans, Denis, De Jager, Philip L., Crane, Paul K., Buxbaum, Joseph D., Murrell, Jill R., Raj, Towfique, Ertekin-Taner, Nilufer, Logue, Mark, Baldwin, Clinton T., Green, Robert C., Barnes, Lisa L., Cantwell, Laura B., Fallin, M. Daniele, Go, Rodney C. P., Griffith, Patrick A., Obisesan, Thomas O., Manly, Jennifer J., Lunetta, Kathryn L., Kamboh, M. Ilyas, Lopez, Oscar L., Bennett, David A., Hendrie, Hugh, Hall, Kathleen S., Goate, Alison M., Byrd, Goldie S., Kukull, Walter A., Foroud, Tatiana M., Haines, Jonathan L., Farrer, Lindsay A., Pericak-Vance, Margaret A., Lee, Joseph H., Schellenberg, Gerard D., St. George-Hyslop, Peter, Mayeux, Richard, Rogaeva, Ekaterina
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641052/
https://ncbi.nlm.nih.gov/pubmed/26366463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1700
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