Global and Local Ancestry in African Americans: Implications for Alzheimer’s Disease Risk

African American (AA) individuals have a higher risk for late-onset Alzheimer’s disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome-wide association study in AAs to date confirmed that six of the AD-related genetic variants originally discovered in EA coho...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement
Main Authors: Hohman, Timothy J., Cooke-Bailey, Jessica N., Reitz, Christiane, Jun, Gyungah, Naj, Adam, Beecham, Gary W., Liu, Zhi, Carney, Regina M., Vance, Jeffrey M., Cuccaro, Michael L., Rajbhandary, Ruchita, Vardarajan, Badri Narayan, Wang, Li-San, Valladares, Otto, Lin, Chiao-Feng, Larson, Eric B., Graff-Radford, Neill R., Evans, Denis, De Jager, Philip L., Crane, Paul K., Buxbaum, Joseph D., Murrell, Jill R., Raj, Towfique, Ertekin-Taner, Nilufer, Logue, Mark W., Baldwin, Clinton T., Green, Robert C., Barnes, Lisa L., Cantwell, Laura B., Fallin, M. Daniele, Go, Rodney C. P., Griffith, Patrick, Obisesan, Thomas O., Manly, Jennifer J., Lunetta, Kathryn L., Kamboh, M. Ilyas, Lopez, Oscar L., Bennett, David A., Hardy, John, Hendrie, Hugh C., Hall, Kathleen S., Goate, Alison M., Lang, Rosalyn, Byrd, Goldie S., Kukull, Walter A., Foroud, Tatiana M., Farrer, Lindsay A., Martin, Eden R., Pericak-Vance, Margaret A., Schellenberg, Gerard D., Mayeux, Richard, Haines, Jonathan L., Thornton-Wells, Tricia A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681680/
https://ncbi.nlm.nih.gov/pubmed/26092349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.02.012
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