Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice

Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer’s disease (AD). A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid β-protein (Aβ), self-associates to form soluble assemblies loosely referred to as “oligomers” and that these are prim...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Mably, Alexandra J., Liu, Wen, Mc Donald, Jessica M., Dodart, Jean-Cosme, Bard, Frédérique, Lemere, Cynthia A., O’Nuallain, Brian, Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641028/
https://ncbi.nlm.nih.gov/pubmed/26215784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.07.008
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