Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn) into mice induce Parkinson’s disease (PD)-like Lewy body (LB) pathology formed by aggregated α-syn in anatomically interconnected regions and significant nigrostriatal degeneration. The aim of the current...

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Publicado en:Neurobiol Dis
Main Authors: Paumier, Katrina L., Luk, Kelvin C., Manfredsson, Fredric P., Kanaan, Nicholas M., Lipton, Jack W., Collier, Timothy J., Steece-Collier, Kathy, Kemp, Christopher J., Celano, Stephanie, Schulz, Emily, Sandoval, Ivette M., Fleming, Sheila, Dirr, Elliott, Polinski, Nicole K., Trojanowski, John Q., Lee, Virginia M., Sortwell, Caryl E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640952/
https://ncbi.nlm.nih.gov/pubmed/26093169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.06.003
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