An Evolutionarily Conserved Autoinhibitory Molecular Switch in ELMO Proteins Regulates Rac Signaling

Dedicator of cytokinesis (DOCK) proteins are guanine nucleotide exchange factors (GEFs) controlling the activity of Rac1/Cdc42 during migration, phagocytosis, and myoblast fusion [1–4]. Engulfment and cell motility (ELMO) proteins bind a subset of DOCK members and are emerging as critical regulators...

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Pubblicato in:Curr Biol
Autori principali: Patel, Manishha, Margaron, Yoran, Fradet, Nadine, Yang, Qi, Wilkes, Brian, Bouvier, Michel, Hofmann, Kay, Côté, Jean-François
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640902/
https://ncbi.nlm.nih.gov/pubmed/21035343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.10.028
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