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Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion

The receptor tyrosine kinase Axl contributes to cell migration and invasion. Expression of Axl correlates with metastatic progression in cancer patients, yet the specific signaling events promoting invasion downstream of Axl are poorly defined. Herein, we report Elmo scaffolds to be direct substrate...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Abu-Thuraia, Afnan, Gauthier, Rosemarie, Chidiac, Rony, Fukui, Yoshinori, Screaton, Robert A., Gratton, Jean-Philippe, Côté, Jean-François
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295393/
https://ncbi.nlm.nih.gov/pubmed/25332238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00764-14
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