An α-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling

The mammalian DOCK180 protein belongs to an evolutionarily conserved protein family, which together with ELMO proteins, is essential for activation of Rac GTPase-dependent biological processes. Here, we have analyzed the DOCK180-ELMO1 interaction, and map direct interaction interfaces to the N-termi...

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Main Authors: Komander, David, Patel, Manishha, Laurin, Mélanie, Fradet, Nadine, Pelletier, Ariane, Barford, David, Côté, Jean-François
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575150/
https://ncbi.nlm.nih.gov/pubmed/18768751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-04-0345
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