Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia

Adult T cell leukemia (ATL) is an aggressive T cell malignancy caused by human T cell leukemia virus type 1 (HTLV-1) and has a poor prognosis. We analyzed the cytotoxic effects of various nucleoside analog reverse transcriptase inhibitors (NRTIs) for HIV-1 on ATL cells and found that abacavir potent...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Tada, Kohei, Kobayashi, Masayuki, Takiuchi, Yoko, Iwai, Fumie, Sakamoto, Takashi, Nagata, Kayoko, Shinohara, Masanobu, Io, Katsuhiro, Shirakawa, Kotaro, Hishizawa, Masakatsu, Shindo, Keisuke, Kadowaki, Norimitsu, Hirota, Kouji, Yamamoto, Junpei, Iwai, Shigenori, Sasanuma, Hiroyuki, Takeda, Shunichi, Takaori-Kondo, Akifumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640626/
https://ncbi.nlm.nih.gov/pubmed/26601161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1400203
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